Aim: To investigate the effect of consumption of different edible oils on postprandial chylomicron size distribution and metabolism in healthy normolipidemic subjects.
Methods: Volunteers received in random order an isocaloric mixed meal containing 40 g of either: palm oil (PO), coconut oil (CO), or rice bran oil (RBO) on 3 occasions. Apolipoprotein (apo) B-48 concentration, a measure of chylomicron particle number, was measured at 0, 4 and 8 hours postprandially in lipoprotein fractions with Svedberg flotation rates (Sf) >400, Sf 20-400 and Sf <20. The trial was registered ACTRN 12614000352606.
Results: Preliminary data indicatethat ~80% of the fasting and postprandial concentrations of apo B-48 is found in the Sf <20 fraction following all test meals. Following consumption of the CO meal a greater proportion of the postprandial apo B-48 response (corrected for baseline levels, incremental area under the curve (IAUC)) were observed in the Sf <20 fractions compared to other oils. However following consumption of the RBO meal a greater postprandial apo B-48 response was observed in all lipoprotein fractions compared with the CO and PO meals.
Conclusion: We observed that following consumption of all oils the majority of the chylomicrons particles were present in the small dense lipoprotein fraction (Sf <20), however differences exist in the postprandial response following consumption of different edible oils.
Funding source: Curtin University