on behalf of the PREVIEW consortium
Background/Aims: PREVIEW is a 6-yr EU project (2013-2018) within the FP7, KBBE program with 12 partners from Europe, plus New Zealand (NZ), Australia (AUS) and Canada. The primary goal is to identify the most efficient lifestyle pattern for prevention of type-2 diabetes (T2D) in a population of pre-diabetic overweight/obese individuals.
Methods: The project includes a 3-yr, 2x2 factorial, randomised clinical trial (RCT) enrolling 2,500 participants across 6 European countries plus NZ and AUS, investigating impact of diet+exercise on T2D incidence and related end-points. Diet compares lower-fat/higher-protein(HP)/lower-glycemic-index (GI) based on DioGenes1 vs. lower-fat/moderate-protein(MP)/ moderate-GI based on Finnish DPS2 and USDPP3; exercise compares moderate (MI) vs. high intensity (HI) activity. An 8-wk weight loss phase on a low-energy diet (LED) for >8% body weight loss is followed by randomisation to weight maintenance in 4 intervention arms (HP/MI, MP/MI, HP/HI, HP/MI) for 3-yr.
Results: NZ and Aus have pre-screened 4,762 adult participants, screened 1,179 in clinic using OGTT, and enrolled 516. LED-weight-loss of >8% was achieved in 75% (n=389) of participants. Average age is 50 yr, with ~ 2/3 female.
Conclusions: PREVIEW, including NZ and AUS, has now completed recruitment and LED phase, with eligible participants continuing into the randomised 3-yr weight maintenance, with completion in 2018.
Funding source(s): EU 7th Framework Programme (FP7/2007-2013) grant no.312057; HRC (14/191) and UoA FRDF, NZ; NHMRC-EU Collaborative Grant, AUS. Cambridge Weight Plan UK donated LED products.