Background/Aims: The MedLey trial is a 6 month dietary intervention study comparing the effects of a traditional Mediterranean diet (MedDiet) with habitual diet on cardiovascular risk factors and cognitive performance in Australians aged 65 years and over. We aim to present the effect of a MedDiet versus a habitual diet (HabDiet) on an oxidative stress biomarker (F2-isoprostane; PGF2a).
Methods: One hundred and fifty-two volunteers (mean age 71 ± 5 years) were randomly assigned to follow either a MedDiet (n=80) or continue their habitual diet (HabDiet; n=72) (control) for 6 months. Plasma PGF2a was measured by GC-MS at baseline and 3 and 6 months. Data were analysed using a linear mixed effects model with age and gender as covariates.
Results: One hundred and thirty-seven volunteers completed the trial (n=70 MedDiet, n=67 HabDiet). Mean plasma PGF2a values for the MedDiet group were 808.5±27.5, 729.3±26.7, 730.4±50.0 pmol/L, at baseline, 3 and 6 months, respectively. Mean plasma PGF2a values for the HabDiet group were 787.8±34.8, 805.9±32.9, 776.4±33.5 pmol/L, at baseline, 3 and 6 months, respectively. There was a significant change over time within the MedDiet group (P<0.0001, 95% CI 34.8,109.3) however, there was no significant difference over time for the HabDiet group, nor was there any difference between dietary group.
Conclusions: Following a traditional MedDiet for 6 months may help reduce oxidative stress in vivo in older Australians which may assist with healthy vascular function and cognitive ageing.
Funding source: NHMRC