Introduction: Diet is significant in the disease susceptibility of individuals. Omega-3s are associated with immune regulatory functions. Omega-3 supplementation has shown reduced inflammation especially in people with inflammatory disorders.
Background/Aim: To investigate the effects of an anti-ageing supplement, Lester’s Oil (About Health® Supplements Ltd) on fatty acid profiles on inflammation (as measured by CRP) in healthy people.
Study Design: double blinded, randomised, placebo controlled with cross-over.
Methods: C Reactive protein (CRP)levels were measured in the blood plasma. These levels rise in response to inflammation. Using serum, the fatty acids were measured and analysed by FAME analysis. The outcomes of interest were taken from the differences between measures for each phase of the trial. A general linear mixed model was fitted to compare the effect of the supplement with a medium chain triglyceride oil [MCT- 8+10 Triglycerides] with adjustments for differences before and after the trial for BMI, gender, and former smoking status.
Results: Thefatty acids EPA, DHA and DPA, showed significant increases (p=6.68E-14; p= 3.09E-09; p=9.65E-09); the fatty acids Oleic acid, Palmitoleic and Myristoleic showed significant decreases (p=0.0026, p=0.0162, p= 0.0216); CRP showed a significant decrease (p= 0.0109).
Conclusions: These results show the supplement was effective in improving key fatty acids (EPA, DHA, DPA) and decreasing inflammation in healthy people as measured by CRP. To achieve this, the preparation has to be bioavailable. The fatty acid and CRP results demonstrated this happened in a short time.
Funding Source: About Health Supplements Ltd