Poster Presentation Joint Annual Scientific Meeting of the Nutrition Society of NZ and the Nutrition Society of Australia

Does caffeine consumption during 50h of sleep deprivation alter glucose metabolism, hunger and satiety ratings? (#P20)

Crystal Grant 1 , Alison Coates 2 , Jill Dorrian 1 , Gemma Paech 1 , Chris Della Vedova 3 , Maja Pajcin 3 , Siobhan Banks 1
  1. Centre for Sleep Research, University of South Australia, Adelaide, SA, Australia
  2. Alliance for Research in Exercise, Nutrition and Activity, University of South Australia, Adelaide, SA, Australia
  3. School of Pharmacy and Medical Sciences, University of South Australia, Adelaide, SA, Australia

Introduction: Sustained operations are common in military and emergency services. In these operations it is not always possible to obtain sleep, resulting in sleep deprivation. Caffeine is a widely used fatigue countermeasure. However, the impact of caffeine on glucose metabolism, hunger, and satiety during sleep deprivation is largely unknown.

Methods: In this double-blinded laboratory based study, participants were assigned to either a caffeine (n=12, 4F, 22.5±3.3y, 21.7±1.5kg/m2) or placebo condition (n=12, 5F, 22.5±2.5y, 22.3±2.1kg/m2). The protocol included one baseline sleep (22:00h–08:00h), 50h sleep deprivation and a daytime recovery sleep (10:00h–19:00h). Caffeine (200mg) or placebo gum was chewed for 5min at 01:00h, 03:00h, 05:00h and 07:00h during each night of sleep deprivation. Meal timing and composition were controlled throughout the study; breakfast composition ≈1611kJ; 16% protein, ≈73% carbohydrate and 3% total fat. Interstitial continual glucose monitors captured 2h post-breakfast levels, at 5min intervals. Hunger/satiety scales were administered at 10:00h after 26h of sleep deprivation.

Results: Relative to baseline (6.1± 0.5mmol/L) sleep deprivation led to increased mean glucose 2h post breakfast at 24h sleep deprived (6.5±0.5mmol/L, p<0.001) and 48h sleep deprived (7.1±0.5mmol/L, p<0.001). There was no difference between placebo and caffeine conditions (p=0.743) on glucose levels. Hunger increased (p=0.001) while satiety decreased (p=0.014) after 26h sleep deprivation. Caffeine did not moderate this effect (hunger p=1.000, satiety p=0.484).

Conclusions:  Results suggest that sleep deprivation impairs glucose metabolism, increases hunger and reduces satiety. Chewing caffeine gum did not influence this effect. 

Funding Source: Defence Science and Technology Organisation, Australian Government, Department of Defence