Background/Aims: Vitamin D may have a protective role in the development of many chronic diseases, including T2DM. The aim of this study was to investigate the association between serum 25OHD, the risk of T2DM and presence of the metabolic syndrome (MetS).
Methods: We analysed the 2009-2010 Victorian Health Monitor survey where information on 25OHD, HBA1c, fasting plasma glucose and presence of the metabolic syndrome were available. Logistic regression analyses were used to evaluate the association between tertiles of serum 25OHD and HbA1c (<5.7% vs. ≥5.7%), fasting plasma glucose (<5.6 mmol/L vs. ≥5.6 mmol/L) and MetS (yes/no). Confounders tested were age, gender, country of birth, income, education, physical activity, smoking status, season, weight, calcium, magnesium, energy intake, television viewing time, sitting time, waist circumference, BMI, and intakes of alcohol, total fat, carbohydrate, protein, retinol, fibre and caffeine.
Results: 3434 Australian adults excluding those with T1DM and T2DM entered the analysis. Greater 25OHD had a lower OR of being associated with the presence of MetS [OR 0.36 (95% CI; 0.27, 0.48), p=0.005], lower OR of a higher HbA1c [OR 0.62 (95% CI; 0.49, 0.77), p=0.004], and a lower OR of higher fasting plasma glucose [OR 0.55 (95% CI; 0.39, 0.77), p=0.004].
Conclusions: Higher 25OHD may have a beneficial effect on MetS and risk of T2DM.
Funding source: N/A